About Diclofenac 75mg tablets
Diclofenac is a pharmacotherapy belonging to drugs classified as phenylacetic acid derivatives. The original formulation of Diclofenac was acetylsalicylic acid. This drug formulation was quite effective, but toxic when given at high doses. Scientists began developing new formulations of acetylsalicylic acid to avoid potential health risks and ended up with Diclofenac.
There is a well-recognized connection that exists between inflammatory processes and painful sensations. This is why the most effective medications for alleviating pain are those that possess both anti-inflammatory and analgesic properties. For example, non-steroidal anti-inflammatory drugs such as Diclofenac are ideal for treating inflammation and pain.
The creation of Diclofenac dates back to 1966. During the first few years of development, Diclofenac was only used as a therapy to treat rheumatoid arthritis. However, because of impressive results related to the ability of Diclofenac to relieve inflammation and pain, over time doctors began to prescribe this medication to patients with other conditions. This is why Diclofenac is currently used in various fields of medicine, which includes surgery, neurology, ophthalmology, and oncology.
Despite the benefits of Diclofenac, a significant problem is that long-term use of this medication increases the risk for cardiovascular-related adverse events. In contrast, short term use of Diclofenac is not associated with the same risk of side effects.
The widespread use of Diclofenac as a medication has only been recognized for roughly 30 years. While other non-steroidal anti-inflammatory drugs have been identified as being effective over this same period of time, the popularity of Diclofenac has not decreased.
Diclofenac is associated with demonstrating therapeutic effectiveness across a wide range of conditions. This medication is produced in various administration types, all demonstrating high levels of success.
Diclofenac can be prescribed in the following forms:
- Solution for intramuscular injection. Issued in ampoules of 3 milliliters, which contain 25 milligrams of active substance
- Coated tablets can contain as much as 25 to 50 milligrams of active ingredient
- Retard tablets contain 75 to 150 milligrams of the active ingredient
- Rectal suppositories are available in packs of 10 with units containing 25 to 100 milligrams of active substance
- Ointment can be issued in 1% concentrations of active substance
- Gel is available either as 1 or 3% active substance
Doctors typically recommend and prescribe Diclofenac to treat the following cases:
- Conditions of the musculoskeletal system, which involve inflammatory and degenerative processes affecting tissues of the body. This may include rheumatoid arthritis, Bekhterev’s disease, arthrosis, spondyloarthritis, and/or osteoarthritis
- Conditions of the spine, which provoke painful sensations. This may include osteochondrosis in different departments
- Various conditions across the rheumatic spectrum, which affect soft tissues of the whole body
- Acute cases of gout
- Inflammatory processes accompanied by pain, which are caused by trauma or various kinds of surgical interventions
- Conditions affecting the gynecological sphere, which are accompanied by pain and inflammation
- Severe conditions associated with inflammation of the ear, throat, nose, and nasopharynx caused by an infectious agent
- Diclofenac should not be prescribed as an independent medicine for treatment of pharyngitis, tonsillitis, and/or otitis
- Non-infectious conjunctivitis, trauma, pain after laser surgery, etc.
Diclofenac is recognized as a medication perfectly combining analgesic and anti-inflammatory properties.
With prolonged treatment with Diclofenac, even at large doses, the majority of patients do not experience adverse reactions. However, clinical studies have identified certain groups of individuals who demonstrate greater susceptibility to adverse reactions when taking Diclofenac.
The following individuals are a greater risk for adverse events when taking Diclofenac:
- Elderly patients over the age of 65 years
- Individuals who have gastrointestinal ulcers
- Individuals who consume spicy, fatty, and fried foods that cause increased gastric secretion
- Individuals taking other non-steroidal anti-inflammatory drugs
- Individuals concurrently being treated with glucocorticosteroids
- Smoking and consumption of alcoholic beverages
- Infection with the bacterium Helicobacter pylori
Individuals who fall in one of the above risk groups should begin taking Diclofenac at the lowest possible dose, which is 100 mg per day.
Prior to prescribing any medication, including Diclofenac, a treating physician must be made aware of all health and medication history of a patient.
For women who are pregnant, Diclofenac should only be taken when the health risk to the woman is higher than the potential negative impact on the fetus. During lactation and breastfeeding, Diclofenac may only be taken in small doses in tablet form.